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KMID : 0380619720040020072
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Korean Journal of Food Science and Technology
1972 Volume.4 No. 2 p.72 ~ p.76
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Studies on Hydroxyamine Derivatives of 2,2´- Methylene bis(3,4,6- trichloroacetoxy benzene)
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Abstract
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Seven new hydroxyamine derivatives of 2,2´-methylene bis(3,4,6-trichloroacetoxy benzene) were synthesized by the Mannich reactions. 13 strains of microorganisms were tested for sensitivity to these derivatives by both paper disk method and tube dilution method. Of these compounds, -NHOH compound displays the most effective antimicrobial activity in vitro against Brevibacterium ammoniagenes, Staphylococcus aureus and Bacillus subtilis. Its minimal inhibitory concentration is 1.6 ㎍/㎖ for Brevibacterium ammoniagenes, and 5 ㎍/㎖ for Staphylccoccus aureus and Bacillus subtilis.
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